reading 6

reading 6 - Isoprenoid 1. Chain elongation:isoprenoid...

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Isoprenoid 1. Chain elongation :isoprenoid allylic diphosphate add to the double bond in isopentenyl diphosphate (IPP). Occur in all organisms . a. Enzymes : i. E : synthesize shorter chain isoprenoid diphosphates 1. FPPase: catalyzes 2 rxns: a. Sequential condensation of DMAPP and GPP with IPP to give FPP Phylogenetic comparisons show that isoprenoid fold originally disocered in avian FPPase is found in all E chain elongation enzymes, in cyclopropanation and cyclization rxns ii. Z : longer chian 2. Cyclopropanation : first pathway specific step in the biosynthesis of sterols and carotenoids. In eukarya, archaea, and some bacteria. 3. Branching : only found in some plants 4. Cyclobutanation : mealybug mating pheromones 4 enzymes involved. they found that all 4 enzymes are evolved from a common ancestor through relatively small changes in the catalytic site. Classes of isoprenoids: - Sterols - Carotenoids - Prenylated proteins - Dolichols - Monoterpenes - Sesquiterpenes The carbon skeleton of isoprenoid are constructed from 3-methyl-1butyl units
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reading 6 - Isoprenoid 1. Chain elongation:isoprenoid...

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