This preview shows pages 1–2. Sign up to view the full content.
This preview has intentionally blurred sections. Sign up to view the full version.View Full Document
Unformatted text preview: through gene duplication and random mutagenesis of the duplicate genes. In sum, this article is fairly convincing. The authors represented their studies very well by both explaining the reactions in details and by providing adequate figures to show the mechanisms. However, the article should include the crystal structures of the enzymes to further demonstrate the similarity. Considering the similar mechanisms of the reaction, the absolute stereochemistry of the products, and the conserved isoprenoid fold in avian FPPase, sterol biosynthesis and several terpenoid cyclases, the likelihood the four coupling enzymes being evolved from a same common ancestor is high....
View Full Document