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LecL26 - Final MONDAY 8 am to 11 am PRICE CETER THEATRE...

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Final MONDAY, December 10, 2007 8 am to 11 am PRICE CETER THEATRE Final includes a total of nine questions; 1 from each chapter, 1 multiple choice and 1 matching Chapters 6-12
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Reversible inhibition Competitive inhibitors Binds to the substrate binding site Non-competitive inhibitors Binds away from the substrate binding site Uncompetitive inhibitors Binds to enzyme-substrate complex Mixed inhibitors Binds to the substrate-binding site and the enzyme-substrate complex
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Competitive inhibition
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Inhibitors bind to the substrate binding site K I = [E][I] [EI] The K i is some measure of the effectiveness of the inhibitor
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Substrate and inhibitor bind to the same site on the enzyme Results in a increase in apparent K m
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Competitive inhibitors affect the K m
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1 v 0 = aKm V max 1 [S] + 1 V max Lineweaver-Burke Plot for Competitive Inhibition
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Example of competitive inhibition Alcohol dehydrogenase uses both methanol and ethanol as substrates; They are competitive inhibitor to each other
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