Lec - Protein Structure & Function Myoglobin A single...

Info iconThis preview shows pages 1–10. Sign up to view the full content.

View Full Document Right Arrow Icon
Protein Structure & Function Myoglobin A single polypeptide chain folds into a functional protein All helical protein Binds to a Heme group Functions as an oxygen storage protein and transport oxygen to muscle
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Myoglobin
Background image of page 2
The Heme Group
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
The Heme Complex in Mb
Background image of page 4
Mb binding to oxygen Mb + O 2 MbO 2 K = [MbO 2 ] [Mb] + [MbO 2 ] [MbO 2 ] [Mb] + [MbO 2 ] Y O2 = [MbO 2 ] = [Mb][O 2 ] K Y O2 = [Mb][O2] K [Mb][O 2 ] K [Mb] + Y O2 = [O] 2 [O 2 ] K + Y O2 = p O 2 K + p O 2
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Oxygen Binding Curve of Mb Y O2 = p O 2 K + p O 2 = p O 2 2p O 2 = 0.5
Background image of page 6
Myoglobin to Oxymyoglobin Hyperbolic binding event As the concentration increases binding sites are saturated p50 (Y O2 at which 50% of Mb is bound to O 2 ) of Mb is 2.8 torr) pO2 of venous blood is 30 torr and arterial blood is 100 torr Mb is fully saturated with oxygen in blood Mb can supply O 2 from blood to muscle
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Hemoglobin A tetrameric protein with two alpha and two beta chains Both chains fold into a Mb- like structure An oxygen carrier protein Provides oxygen to different types of tissues
Background image of page 8
Hb has two different conformations: oxygen-bound and unbound
Background image of page 9

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 10
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 10/28/2010 for the course CHEM 114A taught by Professor Viadhiu during the Fall '08 term at UCSD.

Page1 / 22

Lec - Protein Structure & Function Myoglobin A single...

This preview shows document pages 1 - 10. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online