Lec20 - Vesicle Fusion Membrane Fusion Components NSF (NEM

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Unformatted text preview: Vesicle Fusion Membrane Fusion Components NSF (NEM (N-ethylmaleimide)- sensitive fusion protein) NSF attachment protein (SNAP) SNARE (SNAP receptor) NSF/SNAP complex associates with SNAREs A Model of Vesicle Fusion SNAREs of vesicle (R-SNARE) and the target membrane Q-SNARE Zip together leading to membrane fusion CHAPTER 10 TRANSPORT ACCROSS MEMBRANE Why do we need Transport? Import biological molecules (fuel and building blocks) Export of waste Transport of building blocks or degradation products between organelles and the cytoplasm Regulate osmotic pressure Regulate concentration of certain ions Create gradients of ions across membranes Transport across membranes is usually mediated by proteins Membranes have a hydrophobic core Non-polar or small substances are able to pass through membranes unassisted The passage of polar or charged and large molecules is mediated by proteins Movement of molecules across a membrane resembles a Chemical Equilibrium R = gas constant, 8.314 J/K.mol Equilibrium is affected by the ionic charge and differences in electrical potential R = gas constant 8.314 J/K.mol Z = ionic charge of A F = 96485 C/mol 2200 = in- out membrane potential V 1V = 1 J/C Change in free energy for transport of 1 mol A from the outside to the inside Transport Non-mediated transport non-polar molecules e.g., steroids, oxygen etc Mediated transport polar and charged molecules & large molecules Mediated Transport...
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This note was uploaded on 10/28/2010 for the course CHEM 114A taught by Professor Viadhiu during the Fall '08 term at UCSD.

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Lec20 - Vesicle Fusion Membrane Fusion Components NSF (NEM

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