Lec21 - Transport Proteins Fixed in the membrane Do not...

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Transport Proteins Fixed in the membrane Do not form a channel—selectivity Alternate between two conformations—ensures only specific molecules are transported Binding site is open at one side of the membrane Conformational switch so that the binding site opens at the other end of the membrane
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Erythrocyte Glucose Transporter (GLUT1 Modification at C1 blocks binding at the outer surface Modification at C6 blocks Binding at the inner surface Glucose is transported by switching between two conformations of the transporter
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Mediated Vs Non-Mediated Transport Specificity: Glucose is transported 1000-fold more efficiently than D-Manitol Saturation: Rate of Glucose transport increases until it saturation is reached Competition: Competitors affect transport negatively. Higher glucose concentration is required to reach saturation Inactivation: Transporter can be regulated by modification
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Oxalate-Formate Transporter -OOC-COO- Oxalate Transport Into the Cell H-COO- Formate Transport out of the Cell Some Transporters move more than one substance at a time
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This note was uploaded on 10/28/2010 for the course CHEM 114A taught by Professor Viadhiu during the Fall '08 term at UCSD.

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Lec21 - Transport Proteins Fixed in the membrane Do not...

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