Lec22 - Enzymatic Catalysis General properties Activation...

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Enzymatic Catalysis General properties Activation energy Catalytic mechanisms Lysozyme Serine proteases
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Discovery of enzymes Fermentation in vitro turning glucose into ethanol Postulation of “vital force” Yeast extracts were able to make the reaction go Enzymes were eventually purified from cell extracts
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Life based on enzyme catalyzed reactions Enzymes increase the reaction rate (10 6 -10 12 ) Make it possible for reactions to take place a milder conditions Greater reaction specificity Couple reactions Regulation Enzymatic catalysis Why?
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Enzymes are usually proteins Ribozymes: RNA enzymes that participate in catalyzing RNA hydrolysis or RNA ligation Ribosome: RNA enzyme that catalyzes peptide bond formation (Ribosome)
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Cofactors Inorganic - metal ions Mn 2+ , Mg 2+ ,Cu 2+ , Zn 2+ , Fe 2+ Organic - coenzymes NAD, CoA, Heme Co-substrates vs prosthetic groups Holoenzyme vs apoenzyme
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prosthetic groups: during the
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This note was uploaded on 10/28/2010 for the course CHEM 114A taught by Professor Viadhiu during the Fall '08 term at UCSD.

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Lec22 - Enzymatic Catalysis General properties Activation...

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