AKProblemSet5

AKProblemSet5 - Chemistry Biochemistry 114A Fall 2007...

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Chemistry & Biochemistry 114A; Fall 2007 Problem Set #5 1. i) Draw the oxygen binding curves of A) myoglobin and B) a hypothetical hemoglobin with a Hill coefficient of 1 and the same p 50 value as normal hemoglobin. ii) Would A) or B) be able to deliver about the same amount of oxygen to the tissues as normal hemoglobin? And why? (B) will be able to deliver about the same amount of O 2 to tissues as normal hemoglobin since it has the same P50 value as normal hemoglobin. 2. What is the major secondary structure of myoglobin? Alpha helix What is the function of myoglobin in cells? To store oxygen What is the advantage of hemoglobin over myoglobin in having the quaternary structure to carry oxygen? Allow oxygen to bind cooperatively to Hb. This property enables Hb to bind and release oxygen with small changes in oxygen concentration (partial pressure). 3. Some abnormal hemoglobins have Hill coefficients that are less than that of normal hemoglobin, indicating that their ability to bind oxygen cooperatively has been compromised. i) less than ii) greater than iii) about equal to iv) cannot be determined from the information given 4. Explain how CO 2 affects hemoglobin’s oxygen transport. CO2 affects Hb’s oxygen binding property in two ways; at high CO2 level carbonic anhydrase
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AKProblemSet5 - Chemistry Biochemistry 114A Fall 2007...

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