ProblemSet5 - Chemistry Biochemistry 114A Fall 2007 Problem...

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Chemistry & Biochemistry 114A; Fall 2007 Problem Set #5 1. i) Draw the oxygen binding curves of A) myoglobin and B) a hypothetical hemoglobin with a Hill coefficient of 1 and the same p 50 value as normal hemoglobin. ii) Would A) or B) be able to deliver about the same amount of oxygen to the tissues as normal hemoglobin? And why? 2. What is the major secondary structure of myoglobin? What is the function of myoglobin in cells? What is the advantage of hemoglobin over myoglobin in having the quaternary structure to carry oxygen? 3. Some abnormal hemoglobins have Hill coefficients that are ______ that of normal hemoglobin, indicating that their ability to bind oxygen cooperatively has been compromised. i) less than ii) greater than iii) about equal to iv) cannot be determined from the information given 4. Explain how CO 2 affects hemoglobin’s oxygen transport. 5. Explain how BPG binds to hemoglobin. How does BPG binding affect oxygen binding? Why is it important?
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