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ProblemSet8 - Problem Set 8 Chem 114A 2007 1 Explain why...

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Problem Set 8 Chem 114A; 2007 1. Explain why oxygen can cross a red blood cell membrane without the aid of a transport protein. 2. Gramicidin A is a 15-residue polypeptide capable of forming a helical structure. But an α helix doesn't have a hollow core. How does gramicidin A mediate transport? 3. Describe the features of the KcsA channel from Streptomyces lividans that allow it to transport K + ions selectively. 4. What are the essential features of gated ion channels? 5. Water molecules transiting an aquaporin might be expected to form a hydrogen- bonded chain that snakes through the pore. What deleterious effects on the cell would occur if water molecules were transported in this fashion? 6. Describe the mechanism of the erythrocyte glucose transporter (GLUT1). 7. Distinguish between primary and secondary active transport. 8. Describe the mechanism of the (Na + –K + )–ATPase transporter. 9. Explain why enzymes are stereospecific?
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