lec2 - 1 Lecture 2 Glycolysis 2 Glycolysis yruvate is like...

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Unformatted text preview: 1 Lecture 2 Glycolysis 2 Glycolysis yruvate is like alanine Turning glucose (a 6 carbon sugar) into two pyruvates (3 carbons) and getting 2 ATPs and 2 NADHs Glucose 3 General Features:Compartments Oxidative Phosphorylation mitochondrion Glycolysis cytoplasm Compartments, therefore transport required Plant Cell Animal Cell 4 Glucose enters cell through glucose transporters Or, glucose from breakdown of polysaccharides (glycogen from liver, dietary starches) Or, glucose from biosynthesis (gluconeogenesis) from noncarbohydrate precursors Where does the glucose come from? 5 13-2 Glycolysis Glucose (6 carbons) converted to two molecules of pyruvate (3 carbons) and 2 molecules of ATP (energy capture), with 2 molecules of NAD + reduced to NADH, in 10 reactions. 6 10 reactions: 2 stages Energy Investment Recouping the investment 6 carbons 2 x 3 carbons Net 4 ATP and 2 NADH 7 Glucose First step: Getting a phosphate on carbon #6. Why? 8-3 8 1. Hexokinase (kinase phosphorylation First step: Getting a phosphate on carbon #6. Why? To make high-energy phospho-compounds that can phosphorylate ADP. Also, G6P cannot diffuse across membrane....
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This note was uploaded on 10/30/2010 for the course CHEM 114B taught by Professor Wang during the Winter '09 term at UCSD.

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lec2 - 1 Lecture 2 Glycolysis 2 Glycolysis yruvate is like...

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