lec3 - Lecture 3 Glycolysis Continued 1 10 reactions 2...

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1 Lecture 3 Glycolysis Continued
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2 10 reactions: 2 stages Energy Investment Recouping the investment 6 carbons 2 x 3 carbons
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3 6. Glyceraldehyde-3-phosphate dehydrogenase Dehydrogenase — oxidation Oxidation Where does that electron go? Reduction of NAD +
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4 Where do the electrons go? Nicotinamide adenine dinucleotide From niacin (vitamin B3) This is the only part that does chemistry…
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5 Where do the electrons go? Nicotinamide adenine dinucleotide
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6 6. Glyceraldehyde-3-phosphate dehydrogenase Dehydrogenase — oxidation Phosphorylation: Synthesis of high- energy 1,3-BPG But reaction is endergonic , coupled to exergonic #7 Sixth reaction: synthesis of high-energy compound
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7 Reduction of NAD + Phosphate added
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8 13-7 High-Energy Compounds
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9 7. Phosphoglycerate kinase Seventh reaction — generation of ATP (2 ATP/glucose) Exergonic substrate level phosphorylation
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8. Phosphoglycerate Mutase Why? To make substrate for generating second high- energy compound. First was 1,3-bisphosphoglycerate (#6) and second will be phosphoenolpyruvate. Eighth step — moves phosphate from 3 to 2 on PG.
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lec3 - Lecture 3 Glycolysis Continued 1 10 reactions 2...

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