lec4 - Lecture 4 Pentose Phosphate Pathway 1 Pentose...

Info iconThis preview shows pages 1–11. Sign up to view the full content.

View Full Document Right Arrow Icon
1 Lecture 4 Pentose Phosphate Pathway
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
2 Pentose Phosphate Pathway Required for generation of NADPH Also produces Ribose-5- phosphate (R5P) for nucleotide biosynthesis
Background image of page 2
3 General Features:Compartments Pentose phosphate Pathway — cytoplasm
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
4 Nicotinamide as carrier of electrons
Background image of page 4
5 NAD + vs. NADP + Small chemical difference, big biological difference
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
6 NAD + NADP + Capture energy from metabolism Capture energy from metabolism For ATP generation through oxidative phosphorylation For reductive biosynthesis (fatty acids and cholesterol) NAD + /NADH 1000/1(favors metabolite oxidation) NADP + /NADPH 1/100 (favors reductive biosynthesis) Selective dehydrogenases Selective dehydrogenases
Background image of page 6
7 Glycolysis vs. Pentose Phosphate Glucose 2 Pyruvate + 2 ATP + 2 NADH Pentose Phosphate 36 ATP 38 ATP 3 Glucose-6-Phosphate 1 Glyceraldehyde-3-phosphate + 2 Fructose-6-phosphate + 3 CO 2 + 6 NADPH Glycolysis
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
8 First step of glycolysis — Hexokinase First step: Getting a phosphate on carbon #6. PO 3 2- ATP + + ADP + H + Glucose Glucose-6- phosphate (G6P)
Background image of page 8
9 Instead of second step of glycolysis, Phosphoglucose Isomerase Use Glucose-6- phosphate dehydrogenase 9
Background image of page 9

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
10 Pentose Phosphate Step 1: Glucose-6-phosphate dehydrogenase Glucose 6-phosphate dehydrogenase — extract electrons (from C1), making cyclic ester (lactone) and first NADPH Regulatory (committed) step — regulated by availability of NADP + Glucose-6-phosphate dehydrogenase deficiency — genetic disease marked by oxidative damage of red blood cells
Background image of page 10
Image of page 11
This is the end of the preview. Sign up to access the rest of the document.

Page1 / 34

lec4 - Lecture 4 Pentose Phosphate Pathway 1 Pentose...

This preview shows document pages 1 - 11. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online