lec6 - 1 Lecture 6 Gluconeogenesis 2 Lehninger, Fig. 23-11...

Info iconThis preview shows pages 1–10. Sign up to view the full content.

View Full Document Right Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: 1 Lecture 6 Gluconeogenesis 2 Lehninger, Fig. 23-11 Blood glucose level is critical 3 Gluconeogenesis: Making glucose 4 Mostly in liver, some in kidney Non-carbohydrate precursors ¡ Glycolysis products — 9 Lactate 9 Pyruvate 9 Citric acid cycle intermediates 9 Most amino acids, except Leu and Lys ! Not fatty acids Gluconeogenesis In animal, no conversion from Acetyl-CoA to oxaloacetate Lehninger, Fig. 23-6 Cori Cycle 5 Homolactic Fermentation: Lactate Dehydrogenase L-Lactate NAD + 6 General Features:Compartments Citric Acid Cycle — mitochondrion Gluconeogenesis cytoplasm 7 GAPDH PG kinase PG mutase Enolase Pyruvate Kinase Hexokinase PGI PFK Aldolase TIM Glycolysis: How do you go backwards? Principle: Breakdown and synthesis have key steps that are different 8 Reactions of glycolysis Note difference between Δ G°’ and Δ G Why the difference? 9 • Δ G Negative — Spontaneous reaction • How does ratio of Products/Reactants affect reaction?...
View Full Document

This note was uploaded on 10/30/2010 for the course CHEM 114B taught by Professor Wang during the Winter '09 term at UCSD.

Page1 / 31

lec6 - 1 Lecture 6 Gluconeogenesis 2 Lehninger, Fig. 23-11...

This preview shows document pages 1 - 10. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online