lec7 - Lecture 7 Control Mechanisms for Carbohydrate...

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1 Lecture 7 Control Mechanisms for Carbohydrate Metabolism Glycogen Breakdown vs. Synthesis Glycolysis vs. Gluconeogenesis
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2 Regulatory Mechanisms Allosteric control Enzymatic Modification e.g., Phosphorylation Also, R and T states
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3 Glycogen breakdown vs. synthesis Glycogen metabolism controlled according to cellular need.
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4 Allosteric control AMP + ATP G6P Glucose G6P + Additional layer of control — hormonal regulation and phosphorylation ATP low, AMP high, G6P low -> glycogen breakdown
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5 Glycogen Phosphorylase — covalent modification Glycogen n + P i Glycogen n-1 + Glucose-1-P i Glycogen Phosphorylase Regulatory (rate-controlling) ± Phosphorylated at Ser-14, promotes activity — phosphorylase a ± Dephospho, less active — phosphorylase b OK, What does this have to do with inhibitors and R and T?
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6 Glycogen Phosphorylase a and b Inhibitors: ATP G6P glucose Activator: AMP Relaxed (R) Active Tense (T) Inactive
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7 What phosphorylates Glycogen Phosphorylase? Phosphorylase kinase What controls this in the cell?
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8 What dephosphorylates the enzymes? Enzymes phosphorylated ---glucogen degradation Enzymes dephosphorylated ---glucogen synthesis
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9 Hormonal Control: The hormones Glucagon and Epinephrine promote glycogen breakdown Insulin promotes glycogen synthesis
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lec7 - Lecture 7 Control Mechanisms for Carbohydrate...

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