lec8 - Lecture 8 Citric Acid Cycle(Krebs Cycle 1 Hans Krebs...

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1 Lecture 8 Citric Acid Cycle (Krebs Cycle)
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2 Hans Krebs 1900-1981 Nobel Prize in Physiology or Medicine, 1953
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3 13-2 Glycolysis Glucose (6 carbons) converted to two molecules of pyruvate (3 carbons) And then two molecules of Acetyl-CoA (2 carbons)
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4 Everything feeds into the citric acid cycle What comes out? Energy NADH = (3 ATP) FADH 2 = (2 ATP) GTP = (ATP) 2 Carbons 2 Carbons Takes place in mitochondrion
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5 Coenzyme A (CoA) Derived from Vitamin B 5 High-energy thioester bond to acyl or acetyl groups
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6 Acetyl-Coenzyme A (Acetyl-CoA) Derived from Vitamin B 5 High-energy thioester bond to acyl or acetyl groups CH 3 —C ~ O
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7 1. Citrate Synthase 4Carbons 6Carbons
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8 Oxaloacetate ~ Malate ~ Aspartate Oxaloacetate is α -keto acid of Aspartate ( α -amino acid) Malate is α -alcohol of Aspartate (reduced oxaloacetate) α α α Malate
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9 1. Citrate Synthase 4C 6C MECHANISM???
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10 2. Aconitase Isomerization of citrate to isocitrate — move OH group 6C 6C
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11 3. Isocitrate Dehydrogenase First capture of
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This note was uploaded on 10/30/2010 for the course CHEM 114B taught by Professor Wang during the Winter '09 term at UCSD.

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lec8 - Lecture 8 Citric Acid Cycle(Krebs Cycle 1 Hans Krebs...

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