lec10 - Lecture 10 Mitochondrion and Electron Transport 1...

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Unformatted text preview: Lecture 10 Mitochondrion and Electron Transport 1 lectron Transport: Harnessing electrons from ADH and FADH 2 10 NADH ~ 30 ATP 1. Glyceraldehyde-3- phosphate dehydrogenase 2. Pyruvate dehydrogenase 3. Isocitrate dehydrogenase 4. α− ketoglutarate dehydrogenase 5. Malate dehydrogenase 2 FADH 2 ~ 4 ATP 1. Succinate dehydrogenase e- flow ‘downhill’ To O 2 Reduce O 2 to H 2 O And at the same time create an ion gradient across the membrane by pumping H + The ion gradient drives ATP synthesis 2 Mitochondrion • Ellipsoidal, depending on cell • Origins from bacterial symbiosis? • Contains DNA (and RNA and ribosomes) • Two compartments ¡ Enzymes of electron transport in inner membrane ¡ Increase in inner membrane through infoldings — cristae ¡ Ion gradient generated across inner membrane through electron transport 3 Inner Membrane Outer Membrane H + Cytosol Cytosol Cytosol Cytosol Mitochondrion Cristae Matrix Intermembrane space 4 Terry Frey, SDSU 5 6 How do electrons get from NADH to O 2 ? Specific sequence of electron transfers — follows reduction potential ‘downhill’ Reduction potential?...
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This note was uploaded on 10/30/2010 for the course CHEM 114B taught by Professor Wang during the Winter '09 term at UCSD.

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lec10 - Lecture 10 Mitochondrion and Electron Transport 1...

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