lec11 - Lecture 11 Electron Transport and Oxidative...

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0 Lecture 11 Electron Transport and Oxidative Phosphorylation
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1 Electron Transport Chain
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2 e-
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3 Transfer of electrons from CoQ to Complex III Pumping of 4 H + through the “Q cycle” Transfer of electrons from CoQ (soluble in lipid) Through Iron-Sulfur Protein to cytochrome c 1
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4 From Complex III to Complex IV Electrons to soluble cytochrome c Apoptosis (programmed cell death) — cytochrome c released out of mitochondrion to cytosol
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5 Complex IV: Cytochrome c Oxidase Cytochromes Reduction of O 2 to H 2 O Pumps 2 H + Also uses up 2 H + in reduction of O 2 to add to gradient
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6 Cytochrome c Oxidase dimer 13 subunits — cytochrome a , a 3 , Cu A , Cu B Reduction of O 2 — cytochrome a 3 -Cu B complex
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7 Cytochrome c Oxidase e - from cytochrome c Tyrosine radical involved
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8 Oxidative Phosphorylation: Converting the H + gradient to ATP ATP synthase — a rotary machine Converts energy in H + gradient to ATP synthesis H + gradient called „protonmotive force‟ Remember H + gradient formed by H + pumping by complex I, complex III (CoQ), and complex IV ~ 2-3 H + drives synthesis of a single ATP
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9 1963 to 1965, withdrew completely from scientific research Became architect and master of works for restoration of Glynn House, a mansion in Cornwall, England Furnished a major part of Glynn House for use as a research laboratory 1965 he started research on chemiosmotic reactions Chemiosmotic Theory Peter Mitchell (1920- 1992) Nobel Prize for Chemistry 1978
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lec11 - Lecture 11 Electron Transport and Oxidative...

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