lec15 - Lecture 15 Fatty Acid Catabolism (continued), and...

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Unformatted text preview: Lecture 15 Fatty Acid Catabolism (continued), and Fatty Acid Biosynthesis O 15 SCoA 1 hat if the fatty acid has an odd number of carbons? Propionyl-CoA left Special Case: Odd-chain Fatty Acids 3 Carbon (instead of 2) chain left Propionyl-CoA carboxylase Like pyruvate carboxylase (gluconeogenesis) Uses ATP Activates by carboxylation Methylmalonyl-CoA mutase uses derivative of cobalamin, vitamin B 12 Succinyl-CoA enters citric acid cycle Vitamin B 12 To cytosol Odd chain Fatty acids Malic Enzyme Oxidative decarboxylation (cytosol) Like enzyme in C4 plants Odd chain Fatty acids Citric Acid Cycle What about unsaturated fats? cis double bonds usually starting at C9 ( 9 ) Other double bonds, three-carbon interval (no resonance) O SCoA 1 What about unsaturated fats? 9 12 Two separate problems Enoyl-CoA hydratase cannot work on cis- , double bond Isomerase from cis- 3 to trans- 2 (between ) trans- 2 ( ,) OK for Enoyl-CoA hydratase Problem: Enoyl-CoA hydratase 3 bond Problem: Enoyl-CoA hydratase double bond - costs NADPH Peroxisomes oxidation In animals, shortens long chain fatty acids (>22) and then...
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lec15 - Lecture 15 Fatty Acid Catabolism (continued), and...

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