lec15 - Lecture 15 Fatty Acid Catabolism(continued and...

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Unformatted text preview: Lecture 15 Fatty Acid Catabolism (continued), and Fatty Acid Biosynthesis O 15 SCoA 1 hat if the fatty acid has an odd number of carbons? Propionyl-CoA left Special Case: Odd-chain Fatty Acids • 3 Carbon (instead of 2) chain left • Propionyl-CoA carboxylase — ¡ Like pyruvate carboxylase (gluconeogenesis) ¡ Uses ATP ¡ Activates by carboxylation • Methylmalonyl-CoA mutase uses derivative of cobalamin, vitamin B 12 • Succinyl-CoA enters citric acid cycle Vitamin B 12 To cytosol Odd chain Fatty acids Malic Enzyme • Oxidative decarboxylation (cytosol) • Like enzyme in C4 plants Odd chain Fatty acids Citric Acid Cycle What about unsaturated fats? • cis double bonds • usually starting at C9 ( Δ 9 ) • Other double bonds, three-carbon interval (no resonance) O SCoA 1 What about unsaturated fats? 9 12 Two separate problems • Enoyl-CoA hydratase cannot work on cis- β,γ double bond • Isomerase from cis- Δ 3 to trans- Δ 2 (between α−β ) • trans- Δ 2 ( α,β) — OK for Enoyl-CoA hydratase Problem: Enoyl-CoA hydratase Δ 3 bond Problem: Enoyl-CoA hydratase γδ double bond - costs NADPH Peroxisomes • β oxidation • In animals, shortens long chain fatty acids (>22) and then...
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This note was uploaded on 10/30/2010 for the course CHEM 114B taught by Professor Wang during the Winter '09 term at UCSD.

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lec15 - Lecture 15 Fatty Acid Catabolism(continued and...

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