lec19 - Lecture 19 Amino Acid Breakdown Glucogenic vs...

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Unformatted text preview: Lecture 19 Amino Acid Breakdown Glucogenic vs. Ketogenic Amino Acids Glucogenic lead to… Pyruvate (also ketogenic) a-ketoglutarate Succinyl-CoA Fumarate Oxaloacetate Ketogenic lead to… Acetyl-CoA Acetoacetate Some Glucogenic Amino Acids Alanine, Serine, Cysteine Serine dehydratase (use PLP) Transamination (to pyridoxamine) Recall PLP takes NH 2 off amino acids… Serine Dehydratase: OH leaves and you get pyruvate • Pyridoxal-5’-phosphate (PLP) • Removal of H from C a • Loss of NH 3 What happens to Glycine? • Converted to Ser • Serine hydroxymethyltransferase PLP cofactor Methyl group from N 5 ,N 10-methylene-tetrahydrofolate Methylene group from another Gly — Glycine Cleavage System (complex like pyruvate dehydrogenase) Nonketotic hyperglycinemia Glycine is first converted to Serine N5,N10 methylene Tetrahydrofolate Comes from Tetrahydrofolate (THF) • Transfer of C1 unit, various oxidation states Tetrahydrofolate (THF) comes from Dihydrofolate Dihydrofolate reductase (DHFR) — target of chemotherapy for cancer • Transfer of C1 unit, various oxidation states •...
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This note was uploaded on 10/30/2010 for the course CHEM 114B taught by Professor Wang during the Winter '09 term at UCSD.

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lec19 - Lecture 19 Amino Acid Breakdown Glucogenic vs...

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