lec22 - Lecture 22 Purine and Pyrimidine Biosynthesis 1...

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1 Lecture 22 Purine and Pyrimidine Biosynthesis
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2 Roles of Nucleotides • Precursors to nucleic acids (genetic material and ribonucleic enzymes) • Currency in energy metabolism (e,g., ATP, GTP) • Carriers of activated metabolites for biosynthesis (e.g., CDP, UDP) • Structural parts of coenzymes (e.g., NAD, CoA) • Metabolic regulators and signal molecules (e.g., cAMP)
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3 nucleotide nucleoside
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4 Chapter 3
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5 Purines Pyrimidines
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6 Very Important Molecule 1 5
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7 Feeding the Pigeons John Buchanan and G. Robert Greenberg um…radioactivity
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8 Feeding the Pigeons John Buchanan and G. Robert Greenberg
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9 Precursor for AMP and GMP So, how do you make IMP?
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10 Ribose Phosphate Pyrophosphokinase: Making PRPP From pentose phosphate Also, precursor of pyrimidines and His and Trp Regulated enzyme PP i (good leaving group)
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11 Acquisition of purine N9 PP i gone and hydrolyzed Regulated Step (inhibited by AMP, ADP, ADP, GMP, GDP, GTP)
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12 Glycine Glutamine Adding C4, C5 and N7 in the purine ring reversible only step add >1 atom
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13 Glycine N 10 -formyl THF Glutamine Adding C8 in the purine ring inhibited by sulfonamides
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14 Glycine N 10 -formyl THF Glutamine Glutamine Adding N3 in the purine ring driven by ATP hydrolysis
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lec22 - Lecture 22 Purine and Pyrimidine Biosynthesis 1...

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