lec27 - Lecture 27 Disturbances in metabolism 0 Eating...

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0 Lecture 27 Disturbances in metabolism
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1 Eating Proteins — amino acids (intestines) Protein synthesis Oxidized No storage form Carbohydrates — monosaccharides (intestines) 1/3 made into glycogen (liver) 1/3 made into glycogen (muscle) Oxidized Excess produce triacyl glycerols Fats — chylomicrons Taken up by adipose tissue (lipoprotein lipase)
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3 Starvation Liver’s glycogen depleted Response is gluconeogenesis After ~2 days, most of glucose from gluconeogenesis From protein (muscle) Somewhat from glycerol of triacylglycerols Then, ketone bodies Initially brain depends 1/3 on ketone bodies After ~40 days, brain depends 3/4 on ketone bodies Muscle breakdown slows
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4 Diabetes mellitus Carbohydrate and lipid metabolism is improperly regulated by insulin High blood glucose Higher levels — triacylglycerol hydrolysis, fatty acid oxidation, gluconeogensis, ketone body (ketosis) Kidney malfunctions Cataracts (glucosylation of lens proteins) Type I — patients are completely insulin-dependent 5-10 % of cases Usually childhood Defective pancreatic b
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lec27 - Lecture 27 Disturbances in metabolism 0 Eating...

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