Lect16 - Lecture 16 Fatty Acid Synthesis continued...

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Lecture 16 Fatty Acid Synthesis continued
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Elongases: Longer fatty acids by extending palmitate (16C) Elongases in mitochondrion and ER Mitochondrial elongase — like reversal of β -oxidation Condense (thiolase) acetyl-CoA with acyl-CoA Dehydrogenase/Hydratase/ Reductase (NADPH), rather than FADH 2 ER elongase Condensation of malonyl-CoA with acyl-CoA Like FAS, NADPH-reductions Except, fatty acyl group CoA
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Unsaturated Fatty Acids (double bonds) Terminal desaturases of broad chain-length specificity 9 (double bond between C9-C10) But, cannot make 12 double bond of linoleic acid ( 9,12 ) Linoleic acid is an essential fatty acid Desaturases saturated x 5
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Omega-3 Different patterns of double bonds Note: Double bonds are not conjugated And all are cis Omega-6
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Lastly, Making Triglycerides Glycolysis Or Glyceroneogenesis
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Acyl groups from Acyl-CoA transferred to DHAP or glycerol-3-phosphate backbone lysophosphatidic acid
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Lect16 - Lecture 16 Fatty Acid Synthesis continued...

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