Lecture1 - Welcome to chem114C Biosynthesis of...

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1 Welcome to chem114C: Biosynthesis of Macromolecules Alexander Hoffmann Signaling Systems Laboratory Chemistry and Biochemistry Natural Science Building, Room 3328 [email protected]
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2 Course Objective : The biochemistry of storage, inheritance, repair, transmission, and expression of Genetic Information “The Central Dogma of Molecular Biology” Experiments that revealed what we know today. Experimental techniques that are being used to extend our current knowledge. Fundamentals of Biochemistry by Voet, Voet & Pratt 2nd Edition
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3 Maximizewhat you get out of this class: - Besure you havemastered chapters 3, 4, 5, 6 - Prepare by reading ahead - Takenotes in lecture - Participatein lecture - Attend Discussion Sections - Come to office hours - Work in study groups
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4 Exams and Grading: Textbook is your guide: chapters 23-27 - but not all the details shown in the book are required: come to lectures or look at slides to determine what details are required. - someadditional material will bepresented in Lecture(about 10%) - Exams will beabout all thematerial covered in Lectureand Sections Midterm I (25%) (Thursday of 4th week): 4/23 Midterm II (25%) (Tuesday of 7th week): 5/20 Final (50%) (Thursday 6/12, Location TBA) Midterms arereturned oneweek after. Regraderequests areaccepted within 24 hrs when accompanied with a written note. Grading will beon thecurve. Academic Integrity: http://www- senate.ucsd.edu/manual/appendices/app2.htm#AP14
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5 Lecture chapter Section Tue 4/1 DNA chemistry and structure 3; 23.1 Thu 4/3 DNA/RNA chemistry and structure 23.1-3 Tue 4/8 DNA-protein interactions 23.3-5 DNA/RNA chemistry restriction enzymes, PCR, electrophoresis Thu 4/10 DNA replication I 24.1-2 Tue 4/15 DNA replication II DNA, interactions replication Thu 4/17 DNA damage 24.3-4 Tue 4/22 DNA repair, recombination 24.4-6 Review Practice Exam Thu 4/23 Midterm I: in class room Tue 4/29 Transcription: the prokaryotic machine 25.1 Review of Midterm I Thu 5/1 Transcription: the eukaryotic machine 25.2 0 Tue 5/6 RNA splicing and processing 25.3 transcription splicing 1 Thu 5/8 Translation: the Code and tRNAs 26.1-2 2 Tue 5/13 Translation: the ribosome protein synthesis 26.3-4
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