Midterm1- 2007 - AK

Midterm1 2007 AK - Name CHEM114C Midterm I ID Please write your name on each page and look through the entire exam before beginning your answers

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Name ________________________________ CHEM114C Midterm I April 24, 2007 ID#________________________________ Please write your name on each page and look through the entire exam before beginning your answers. Your exam should have 7 pages including this cover page, with a total of 6 questions. Be certain that all work you want graded is written in permanent ink, and is legible. Your score 1. (20)_________ 2. (20)_________ 3. (20)_________ 4. (20)_________ 5. (20)_________ 6. (20)_________ Total (120)______________
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Name ________________________________ 1. DNA chemistry Drawn below is a skeleton of a base pair. (a) Draw the functional groups to make it a G:C bp. (5) (b) Use conventional numbering scheme to number the ring atoms for both bases. (5) (c) Show the major and minor groove sides of this base pair. (5) (d) Show all the hydrogen bond acceptor and donor groups in the major groove side. (5) Based on Fig. 23.1. (lower panel) (This is pretty detailed but important – give partial credit when deserved.)
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Name ________________________________ 2. DNA helix properties Consider a 1,000,000 bp DNA fragment: (a) What is the contour length (10) (showing your work is as important as the right answer) (i) when naked, in the B-form (ii) when packaged into a 11nm fiber. (iii) when packaged into a 30nm fiber. (b) What is the contour length of the total naked duplex, when a 500,000 bp stretch suddenly switches to the Z-DNA conformation? (5) (c) Within the cell, what may the consequences to transcription be of such a switch in helical conformation? Provide an answer in terms of the properties of Z- and B-DNA. (5) (a) (i) 1,000,000 x 0.34nm = 340μm (ii) 340μm devided compaction ratio of 7 = 50μm or alternatively: 1,000,000 / 166 or 200 = 5,000 to 6,000 nucleosomes. Each is 8nm, which
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This note was uploaded on 10/30/2010 for the course CHEM 114C taught by Professor Alexanderhoffmann during the Spring '08 term at UCSD.

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Midterm1 2007 AK - Name CHEM114C Midterm I ID Please write your name on each page and look through the entire exam before beginning your answers

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