Lecture 6 for Handout sheet, 05-25-10

Lecture 6 for Handout sheet, 05-25-10 - Announcements 1...

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Announcements 1. Office hours for Dr. Martins-Green: Tuesdays – 3:30 to 4:30pm in 2117 BSB Thursdays – 6:30 to 7:30pm in 1103 BSB 1. Final exam on June 10th 11:30-2:30 pm in this room 1. Final exam is comprehensive with 25 points for the lecture material before the midterm, 25 points from the papers and 150 points for the material since the midterm. 1. Question/answer session for Dr. M-G: ????
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Summary of Lecture on 05-20-10 1. Human development begins with fertilization in the Ampulla to development of the morula as it travels down the oviduct. 2. Cleavage occurs by compaction 3. Attachment to the uterine wall occurs in the blastocyst stage 4. The blastocyst assumes the shape of a flat disc much like in the chick. 5. The same events occur in a very similar manner in mouse except that the
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Outline 1. Development of Twins in humans 1. Mechanisms of somite development 2. Neuro Crest cell development: initiation of migration migration pathways differentiation
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Somite Development Somite Development Somites form from the mesoderm that comes to lie along the dorsal side of the embryo during gastrulation. This mesoderm is called pre-somitic mesoderm
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2 Somite Development Somite Development As the embryo develops the pre-somitic mesoderm is the region between the last formed somite and the regressing node. The somites develop as pairs on either side of the notochord. Each pair takes about 90 min to form. Fig. 4.5 Fig. 4.5
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Somite Development Somite Development As new cells are being added to the pre-somitic mesoderm at the posterior end, somites are forming at the anterior end. It appears that the rate of somite formation is determined by an internal “clock” in the pre-somitic mesoderm. Fig. 4.5 Fig. 4.5
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Somite Development Somite Development This internal “clock” is due to cyclic gene expression. The gene that is the best
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Lecture 6 for Handout sheet, 05-25-10 - Announcements 1...

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