Lecture 7, for presentation, 05-27-10

Lecture 7, for presentation, 05-27-10 - Announcements 1....

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Announcements 1. Office hours for Dr. Martins-Green: Tuesdays – 3:30 to 4:30pm in 2117 BSB Thursdays – 6:30 to 7:30pm in 1103 BSB 1. Final exam on June 10th 11:30-2:30 pm in this room 1. Final exam is comprehensive with 25 points for the lecture material before the midterm, 25 points from the papers and 150 points for the material since the midterm. 1. Question/answer session for Dr. M-G: Tu the 8 th 5:30-7:00pm in LSP 2550 1. iEval is now opened
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Summary of lecture on 05-25-10 1. Somites form from the pre-somitic mesoderm that comes to lie along the dorsal side of the embryo during gastrulation. 2. Somites develop in pairs and each pair takes 90 minutes to form. 3. The cyclic expression of the genes c-hairy and Lunatic fringe is critical. The latter potentiates Delta/Notch activity. 4. The opposite gradients of FGF8 and RA control the number of somites that develop. 5. Somites develop in a temporal and spatial order and hence give rise of different types of vertebrae.
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Summary of lecture on 05-25-10 6. Somites are composed of dermamyotome (myotome and dermatome) and sclerotome. 7. Signals from the notochord and basal neural tube induce scleratome. Sonic hedghog is critical in this process 8. Hox genes are also very important in establishing the pattern of the somites 9. There are four separate clusters of Hox genes in vertebrates, Hox a, b,c, d 10. Neural crest cells develop in the dorsal portion of the neural tube. 11. They undergo an epithelial to mesenchymal transition and migrate out of the tube following 3 distinct pathways.
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NCC migration NCC migration If you invert a somite in such a way that the anterior portion now becomes posterior the neuro crest cells will migrate the same through the anterior region which now is posterior Fig. 7.38 Fig. 7.38
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2 Neural Crest Cell Fates Neural Crest Cell Fates Neural crest cells migrate from the neural tube to give rise to: cartilage (in the head) dermis pigment cells medullary cells of the adrenal gland glial Schwann cells peripheral and autonomic system neurons.
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Derivatives of NCC Derivatives of NCC Fig 9.20 Fig 9.20
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2 Question? Question? How did scientists find this out? How did scientists find this out? From transplant experiments From transplant experiments
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2 How is it known what NCC How is it known what NCC differentiate in differentiate in From transplant From transplant experiments experiments Nicole Le Douarin invented this technique. She used quail NCC and transplanted them into the chick neural tube and then followed their fate. She could do this because quail cells have very distinct nuclei that can be detected in histological section Fig. 4.6 Fig. 4.6
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2 How is it known what NCC How is it known what NCC differentiate in differentiate in Today we use fluorescent antibodies Vital dies such as DiI
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Movies Movies NCC migration NCC migration
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Types of blood vessel development: 1. Vasculogenesis 1. Angigenesis a) Non-sprouting angiogenesis By intussusception By bridging b) Sprouting angiogenesis Outline
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2 Blood Vessel Development Blood Vessel Development Vasculogenesis
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This note was uploaded on 10/31/2010 for the course CBNS 108 taught by Professor Green,demason during the Spring '10 term at UC Riverside.

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Lecture 7, for presentation, 05-27-10 - Announcements 1....

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