Lecture 9 - Professor Anupama Dahanukar Entomology Genomics...

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Professor Anupama Dahanukar Entomology Genomics 2234C anupama.dahanukar@ucr.edu (951) 827-5742 Office Hours: Thursdays 3:30 – 5 PM Wednesdays 3:30 – 5 PM
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Lecture schedule Lecture 8: Embryonic patterning (A-P axis) Lecture 9: Embryonic patterning (Segmentation and Homeotic genes) Lecture 10: Embryonic patterning (D-V axis)
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Segmentation
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Localized activity of zygotic genes controls embryo development Maternal effect genes Gap genes Pair-rule genes Segment polarity genes Homeotic genes Segmentation Polarity Identity
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Gradients of Bicoid and Nanos proteins mRNA Protein Bicoid Nanos
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Gap genes Hunchback Giant Krüppel Knirps Tailless
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Pair-rule genes Fushi tarazu protein (grey) Even-skipped protein (brown)
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Combinatorial activity of gap genes regulates pair-rule gene expression
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Segment polarity genes Engrailed protein (green)
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Summary: cascade of gene activation establishes segmentation along the A- P axis
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Key concepts Maternal effect genes establish A-P and D-V axes in the egg Protein gradients establish positional
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Lecture 9 - Professor Anupama Dahanukar Entomology Genomics...

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