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Lecture 11 - Asymmetric divisions of a neuroblast...

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Lecture schedule Lecture 8: Embryonic patterning (A-P axis) Lecture 9: Embryonic patterning (Segmentation and Homeotic genes) Lecture 10: Embryonic patterning (D-V axis) Lecture 11: Specification of cell identity
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The embryonic nervous system
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Neuroblast specification and division Proneural genes Lateral inhibition Asymmetric cell division Photoreceptor differentiation Cell-cell interactions
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Dorso-ventral position specifies different tissues amnio- serosa dorsal ectoderm neuro- ectoderm mesoderm mesoderm formation fate map dorsal ventral
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Neurons arise from proneural clusters
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Proneural genes are activated in equivalence groups of neuroectoderm cells Achaete-scute complex (AS-C) AS-C genes are activated in proneural clusters AS-C genes are regulated by A-P and D-V genes AS-C genes encode basic helix-loop- helix transcription factors
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Signaling via the Notch receptor inhibits neuroblast specification
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Lateral inhibition allows specification of only one neuroblast per proneural cluster
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Neuroblast development begins with
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Unformatted text preview: Asymmetric divisions of a neuroblast Asymmetric divisions of a neuroblast Adult organs arise from imaginal discs Development of ommatidia: morphogenetic furrow Photoreceptor cells are specified by cell-cell interactions R7 is specified by sevenless and Bride-of-sevenless eyeless/Pax6 : a “master regulatory gene” for eye development eyeless/Pax6 : a “master regulatory gene” for eye development Key concepts • Lateral inhibition allows only one from a group of equivalent cells to adopt a specific fate • Lateral inhibition is used to achieve appropriate spacing of differentiated cells • The Notch receptor is a critical component of lateral inhibition • Neuroblasts divide asymmetrically to give rise to neuroblasts and GMCs • Photoreceptors are specified by sequential recruitment via cell-cell interactions • Eye development in animals is initiated by the highly conserved eyeless/Pax6 genes...
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