Lecture Images part 3

Lecture Images part 3 - Lecture 12- The Limbic System...

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Unformatted text preview: Lecture 12- The Limbic System Announcements: Assignment : In Nolte read Chapter 23, The limbic system, pp. 594-605. For next lecture : In Nolte read Chapter 24, Formation, modification, and repair of neuronal connections, pp. 616-626. Lecture Outline : Overall function of the limbic system Components of the limbic system The amygdala: anatomy and connections The amygdala: overview of functions Introduction to the hippocampus The limbic system is interposed between hypothalamus and neocortex The limbic system The hippocampus, amygdala, and fornix The two primary subsystems of the limbic system: the amygdala and hippocampus. The basal forebrain The amygdalar nuclei and connections Amygdala afferents to the medial (green), central (red) and basolateral (blue) nuclei of the thalamus B = brainstem (via MFB) S = septal area (basal forebrain) Amygdala efferents Patient GL, with a rare autoimmune syndrome resulting in degeneration of all primary 1a somatosensory fibers still experiences the pleasure of gentle touch. The insula, in addition to containing primary gustatory cortex, is important for general sensations of pleasure and well-being. The amygdala projects to reward pathways in the ventral striatum (nucleus accumbens). This shows the distribution of the D3 receptor (dopamine is a very important transmitter in reward pathways) in a normal individual (A-D) and a cocaine addict (E). Areas of increased blood flow, measured by fMRI, in subjects watching videotapes of the faces of patients in pain (A) and themselves receiving a painfully hot stimulus (B) . In both conditions, there was activation of medial prefrontal cortex (A1-2, B1-2) and the insula (A3, B3) . Only when watching the faces of others in pain was there activation of the face-recognition area in the right occipitotemporal gyrus ( A4 , green arrow ) and the left amygdala ( A4 , red arrow ). Regulation of emotions by conscious effort involves both dorsolateral and ventromedial prefrontal cortex. The 52 year-old patient with bilateral occipital lobe lesions exhibiting emotional blindsight (recognition of emotion without awareness). Hippocampus and fornix in coronal sections and 3D reconstruction The fornix and anterior commissure The mammillary bodies are the target of fornix fibers Ammonites: Ammon: Hippocampus is from the Latin, Seahorse Famous patient H.M.: a major clue to understanding hippocampal function For reference only: Lecture 13- The Hippocampus: Intrinsic Circuitry and Physiology Announcements : Exam 2 grades will be posted today. The average was a 58% (about the same as the first exam). Assignment : In Nolte read Chapter 24: Formation, modification, and repair of neuronal connections, pp. 616-626....
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This note was uploaded on 10/31/2010 for the course CBNS 116 taught by Professor Todda.fiacco during the Spring '10 term at UC Riverside.

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Lecture Images part 3 - Lecture 12- The Limbic System...

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