Biol168_10F_Lecture 1_24Sep2010

Biol168_10F_Lecture 1_24Sep2010 - Dr. Morris Maduro, UC...

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Dr. Morris Maduro, UC Riverside Biology 168 – 10F – Lecture 1, page 1 Lecture 1: History of developmental biology, genetic equivalence, concepts. Textbook: 2nd edition: pp. 1-22; pp. 323-325. 3rd edition: 1-29; 327-329. Some figures in these notes are redrawn from Wolpert et al. (2nd edition). Biology 168 - Developmental Biology: We will study embryonic development of animals . We all start out as a single cell . How does that single cell, through cell divisions, direct particular cells to become one cell type, and others to do something completely different? How do the mechanisms that operate during development undergo change over evolutionary time to produce different animals? Developmental biology is a field that crosses many disciplines: anatomy, experimental embryology, evolution, molecular biology, cell biology and genetics. Many of the molecular mechanisms that drive development in lower animals also do so in higher animals. In humans, abnormal development leads to birth defects, and cancer. Therefore, the knowledge we gain from working on model animals can apply to all animals, including humans. The goals of this course are to learn: • universal principles that apply to how embryos develop, from fertilization onwards. • the molecular mechanisms behind many of the remarkable events that occur during embryogenesis. • that nature is a tinkerer: widely different animals re-use similar molecular strategies, and a species can often re-use the same molecular pathways many times in development. • that the driving force for development is all in an organisms’ genetic makeup . We will learn about genes that direct specific events in development. We will learn how elaborate control mechanisms for gene expression act to restrict gene activity to particular places and times in the embryo. We will also see that small changes in genes drive evolutionary change. • about modern tools that developmental biologists use to probe molecular events in embryology. • principles in the context of several model systems , in which the most information is known because these systems give us different tools for experimental manipulation and allow us to identify the molecules that are important in development, and to assess the effects of their removal. • relationships between the phenomena you learn about in the course to human health issues, such as stem cells, cloning, and assisted reproductive technology. Structure of the Course Lecture notes will be made available from iLearn before lecture. The best strategy is to download and read them before class. You are not required to buy a textbook, but you must buy an H-ITT remote (clicker) from the UCR Bookstore . Part of the Class Participation grade will come from responses to in- class questions. Purchase your clicker and register it on http://clickers.ucr.edu before Friday, October 8, 2010. If you already have a clicker, it has to be registered again. Unless told otherwise, clicker points are given for correct answers only, and you must be present in the room at the time the clicker responses are
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This note was uploaded on 10/31/2010 for the course BIOL 168 taught by Professor Maduro during the Fall '10 term at UC Riverside.

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Biol168_10F_Lecture 1_24Sep2010 - Dr. Morris Maduro, UC...

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