NCBI Worksheet - NCBI Worksheet: See the handout on our...

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NCBI Worksheet: See the handout on our website. Name: Shayna Russell GSI & Sect # Dale 108 Station # 5 1. Name three databases other than Entrez Gene that you can use to find information related to your gene. What kind of information is available on these databases? Genbank – protein database BLAST – gene information OMIM – articles about the gene 2. a) What are the score and E-value for your top hit? Score = 66 and e-value = 1x10 -11 b) What is the percent identity between your query and top hit? 100% c) How many amino acids align? 20 3. a) What is the official symbol and full name of your gene? PSEN1 presenilin 1 b) What specific biochemical processes does the protein encoded by your gene perform? Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins. These disease-linked mutations result in increased production of the longer form of amyloid-beta. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma- secretase activity or themselves are protease enzymes. c) Name one fact from the published literature relevant to your gene.
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NCBI Worksheet - NCBI Worksheet: See the handout on our...

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