6th_lecture

6th_lecture - MCB 102 Professor Fyodor Urnov Lecture 6 ASUC...

Info iconThis preview shows pages 1–3. Sign up to view the full content.

View Full Document Right Arrow Icon
MCB 102 Professor Fyodor Urnov 06/29/10 Lecture 6 ASUC Lecture Notes Online is the only authorized note-taking service at UC Berkeley. Do not share, copy, or illegally distribute (electronically or otherwise) these notes. Our student-run program depends on your individual subscription for its continued existence. These notes are copyrighted by the University of California and are for your personal use only. D O N O T C O P Y Sharing or copying these notes is illegal and could end note taking for this course. LECTURE Today we'll continue meeting all of the amino acids. I believe yesterday we went through glycine, proline, and glutamate. Today we will start off with amino acids that carry information. Serine (S, Ser), Threonine (T, Thr), and Tyrosine (Y, Tyr) We're used to nucleic acids coding for information but these amino acids are able to carry it because they all have an -OH group in their side chains. I want you to remember them by knowing that these three are responsible for the majority of signaling molecules in a cell. They are able to do so by undergoing post translational modification (PTM) by replacing the -OH with a phosphate group producing phosphoserine, phosphothreonine, phosphotyrosine. PTM is incredibly important for cancer research as metastatic melanoma is caused by the over-phosphorylation of kinases. Serine's structure Threonine’s structure Tyrosin'es structure The most frequent kinase mutation is BRAF(V600E), which has been shown to drive many cancers. The mutation results in the activation of the enzyme by binding strongly to ATP. This brings me to a fantastic type of question that could be seen on the midterm. If the valine is replaced by
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
MCB 102 ASUC Lecture Notes Online: Approved by the UC Board of Regents 06/29/10 D O N O T C O P Y Sharing or copying these notes is illegal and could end note taking for this course. 2 glutamate, which has a negative charge, shouldn't the mutation result in decreased binding to ATP since ATP is also negatively charged? I definitely encourage you to read the Plexecon articles in the New York Times which you can find at http://topics.nytimes.com/top/news/health/series/tar se . However, note that in the studies the same type of cancer but one that occurs in cholera was not cured by this drug. Student : It looks like the drug number article in this article is different from the one you put up. They have not released the chemical structure of the
Background image of page 2
Image of page 3
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 10/31/2010 for the course MCB 67290 taught by Professor Urnov during the Summer '10 term at Berkeley.

Page1 / 5

6th_lecture - MCB 102 Professor Fyodor Urnov Lecture 6 ASUC...

This preview shows document pages 1 - 3. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online