6th_lecture - MCB 102 Professor Fyodor Urnov Lecture 6 ASUC...

Info icon This preview shows pages 1–3. Sign up to view the full content.

View Full Document Right Arrow Icon
MCB 102 Professor Fyodor Urnov 06/29/10 Lecture 6 ASUC Lecture Notes Online is the only authorized note-taking service at UC Berkeley. Do not share, copy, or illegally distribute (electronically or otherwise) these notes. Our student-run program depends on your individual subscription for its continued existence. These notes are copyrighted by the University of California and are for your personal use only. D O N O T C O P Y Sharing or copying these notes is illegal and could end note taking for this course. LECTURE Today we'll continue meeting all of the amino acids. I believe yesterday we went through glycine, proline, and glutamate. Today we will start off with amino acids that carry information. Serine (S, Ser), Threonine (T, Thr), and Tyrosine (Y, Tyr) We're used to nucleic acids coding for information but these amino acids are able to carry it because they all have an -OH group in their side chains. I want you to remember them by knowing that these three are responsible for the majority of signaling molecules in a cell. They are able to do so by undergoing post translational modification (PTM) by replacing the -OH with a phosphate group producing phosphoserine, phosphothreonine, phosphotyrosine. PTM is incredibly important for cancer research as metastatic melanoma is caused by the over-phosphorylation of kinases. Serine's structure Threonine’s structure Tyrosin'es structure The most frequent kinase mutation is BRAF(V600E), which has been shown to drive many cancers. The mutation results in the activation of the enzyme by binding strongly to ATP. This brings me to a fantastic type of question that could be seen on the midterm. If the valine is replaced by
Image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
MCB 102 ASUC Lecture Notes Online: Approved by the UC Board of Regents 06/29/10 D O N O T C O P Y Sharing or copying these notes is illegal and could end note taking for this course. 2 glutamate, which has a negative charge, shouldn't the mutation result in decreased binding to ATP since ATP is also negatively charged? I definitely encourage you to read the Plexecon articles in the New York Times which you can find at http://topics.nytimes.com/top/news/health/series/tar get_cancer/index.html?scp=1&sq=PLX4032&st=c se . However, note that in the studies the same type of cancer but one that occurs in cholera was not cured by this drug. Student : It looks like the drug number article in this article is different from the one you put up.
Image of page 2
Image of page 3
This is the end of the preview. Sign up to access the rest of the document.

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern