Alcohol - CNS DEPRESSANTS All affect the GABA-A receptor ALCOHOL History PHARMACOKINETICS-Oral Route of administration-Absorption*simple-small

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CNS DEPRESSANTS All affect the GABA-A receptor ALCOHOL History PHARMACOKINETICS: -Oral Route of administration -Absorption:*simple-small molecule *soluble in water and lipids *neutral particle *diffuses easily through membranes ALCOHOL Factor influencing Absorption: *type/amount of food in the stomach. *dosage- proof (concentration of alcohol is 1/2 of the proof) Distribution: -distributed through-out all body fluids and organs -90% reaches the blood and then crosses the blood brain barrier Blood Alcohol Level (BAL) Concentration of Alcohol in Whole Blood Metric Measurements and Percent BAL Expressed in Terms of milligrams (mg) of Alcohol per 100 milliliters (ml) of whole blood Conversion to percent involves moving the decimal point three places to the left or right. For example, a BAL of 80 mg per 100 ml (or 80 mg/dl) is the same as 0.08 percent. Blood Alcohol Concentration: Amount of alcohol in the blood, weight of alcohol per 100 units of blood 1
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.05 Mild intoxication: Feel warm, skin flushed; impaired judgment; decreased inhibitions .1 Obvious intoxication: Impairment of judgment, attention, muscular performance, and slowing of reflexes .15 Obvious intoxication: muscular in coordination; slurred speech; double vision; memory loss .25 Extreme intoxication: Reduced response to stimuli; inability to stand; vomiting; incontinence .35 Coma: Unconsciousness .5 Death likely: Alcohol's LD50 ALCOHOL Metabolism: stomach (10-15%) and liver (80%) Two steps in alcohol metabolism release of calories rate is zero order kinetics (Constant rate) MEOS: Microsomal ethanol-oxidizing system Normally 5-10% , chronic 50-65% ALCOHOL Metabolism: LIVER Interferes with other metabolism. Cirrhosis
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This note was uploaded on 11/02/2010 for the course PSYC 330 taught by Professor Lisman during the Spring '08 term at Binghamton University.

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Alcohol - CNS DEPRESSANTS All affect the GABA-A receptor ALCOHOL History PHARMACOKINETICS-Oral Route of administration-Absorption*simple-small

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