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CANNABINOIDS - CANNABINOIDS Hemp plant Cannabis sativa...

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CANNABINOIDS Hemp plant Cannabis sativa: Marijuana a. Male --no real uses outside of hemp cultivation (fiber, oils and seed) b. Female -- High Production of resinous THC glands -- active ingredient. *The chief active ingredient is: delta-9-tetrahydrocannabinol ( THC ) Over 60 cannabinoid compounds Marijuana: flowering tops & leaves of the dried plant Dried leaves containing seeds & stems, grayish-green-brown color It is smoked in pipes or in hand-rolled cigarettes: "joints." Hashish ("hash"): dried-caked resin from flowers & leaves of female plants higher THC concentration-more potent soft or hard chunks -brown to nearly black Hash is mixed with tobacco and smoked in pipes or joints. The most potent preparation other than pure THC is hash oil Change in THC content across the years in marijuanna: 1960’s 1.5% THC 1980’s 3-3.5% THC 1990’s 3.5% THC 2000’s 5.03-5.14% Some as high as 11.4% Synthetic Cannabinoids Synhexyl (Parahexyl): CB1 agonist ? Nabilone: chemotherapy -induced nausea Dronabinol (Marinol): nausea & appetite suppression Nantradol: opiate withdrawal, pain 1
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Rimonabant: reduction of appetite, CB1 inverse agonist Sativex: Spray used in the UK to treat pain I. History of cannabis I. Who uses Marijuana Therapeutic Uses: USDA- none—but states (AZ, CA) vary has been tested for treatment of: *asthma *epilepsy *glaucoma *anorexia nervosa *nausea (anti-cancer therapy) “medical Marijuana” PHARMACOKINETICS: 1. Route of administrations Smoked: "joint" contains 2.5-5 mg of THC
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