Psyc 330 Notes - 8/30/2007 Questions of the day: 1) define...

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8/30/2007 Questions of the day: 1) define a drug a. a substance the alters the physiology of the body that is not used for sustenance 2) what is a psychoactive drug a. influences physiology and then behavior 3) what is a ligand? a. An endogenous substance that is biologically active 4) what is psychocology a. The study of drugs and how drugs affect the brain and behavior 5) What factors impact the affect of drugs a. Route of administration, previous/current drug history, age or physiological state 6) Why is drug abuse today different today than it was in the past a. Drugs from all cultures are available, active ingredients have been isolated, synthetic derivatives have increased potency and maximum efficacy 7) What is a self administration study a. When an animal is put in a skinner box and is allowed to self administer drugs to determine abuse potential 8) What part of the brain do all drugs of abuse affect a. Reward pathway 9) The goals of neuroscience are to create new _______ to treat drug abuse I. Some basic pharmacology a. Pharmacodynamics i. The study of the biochemical and physiological effects of drugs – “what does the drug do to the body?” b. Describing doses i. Milligrams: 1/1000 of a gram ii. Doses given in accordance to body weight iii. Dose response relationships – the relationship between the amount of drug and the degree of response change iv. Dose response curves 1. Individual response curves a. The effect a single drug will have on some biological measure on a singe individual at varying doses 2. Group response curves a. A number of participants chosen from a given population. A different dose is given to a subset of members from the group, thus each member gets only one dose v. ED50 – the median effective dose, i.e. effective in 50% of subjects
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vi. LD50 – median lethal dose, i.e. will kill 50% of subjects tested c. Drug safety i. Therapeutic index (TI) 1. TI = LD50/ED50 ii. High = safe, low = danger, depends on therapeutic use iii. Potency and effectiveness 1. The extent of the drugs effect 2. Potency a. differences in the ED50 b. Potency refers to the concentration of drug required to produce effect c. If a smaller dose of drug A is needed than Drug B to produce an effect, drug A is more potent than drug B 3. Effectiveness a. Differences in maximum effect that drugs will produce at any dose b. The degree to which a drug can produce an effect
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Psyc 330 Notes - 8/30/2007 Questions of the day: 1) define...

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