TOPIC 3 - OLERANCE,DEPENDENCE,ADDICTION T

Info iconThis preview shows pages 1–3. Sign up to view the full content.

View Full Document Right Arrow Icon
TOLERANCE, DEPENDENCE, ADDICTION                                  Homeostasis:  a state of equilibrium or balance.   When homeostasis is disrupted the system operates  1. Drug Tolerance:        *  decreased effect of a drug with repeated administration *  increased doses of the drug are needed TYPES OF TOLERANCE: I.)  PHARMACOLOGICAL TOLERANCE:   a.)  Metabolic tolerance: repeated administration causes the liver to accelerate  synthesis of drug metabolizing enzymes. - Metabolized at a faster rate, decreasing its rate of action, more drug  must be taken b) Cellular adaptive tolerance:  - Receptors in the brain adapt (sensitization, up regulation, desentization,  down regulation) - Changes in amount of neurotransmitter released (increases, depletion) II. Cross tolerance: Tolerance to a closely related drug that has not been previously administered Cross tolerance is observed to other drugs from the same class a) pentobarbital = diazepam b) morphine = methadone c) pentobarbital  morphine d) morphine  diazepam III.  Tolerance does not develop equally to all effects of a drug IV the degree and rate of tolerance development varies with different drugs 1
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
2.  PSYCHOLOGICAL TOLERANCE: Adjustments of behavior through experience to compensate for a drugs effects  Learning plays an important role in psychological tolerance Environment:
Background image of page 2
Image of page 3
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 11/02/2010 for the course PSYC 330 taught by Professor Lisman during the Spring '08 term at Binghamton University.

Page1 / 6

TOPIC 3 - OLERANCE,DEPENDENCE,ADDICTION T

This preview shows document pages 1 - 3. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online