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BIPN140 Lecture 2 - Lecture 2 BIPN 140 Electrical Signaling...

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Lecture 2 September 28, 2010 BIPN 140 Reading: Chapter 2 Electrical Signaling Signals recorded depend on recording techniques Galvani - 1791 Extracellular recording Injury potential - Bernstein - 1902 Intracellular recording The Resting Potential: -40 to -100 mV Intracellular impermeant anions (proteins) Selective permeability to cations (particularly K + ) Asymmetry of permeable cations (particularly K + ) Nernst equation; Nernst (equilibrium) potentials Goldman-Hodgkin-Katz equation Na + /K + pump Depolarization and Hyperpolarization By injection of current with microelectrodes positive in/ negative out - depolarization negative in/ positive out - hyperpolarization By excitatory/inhibitory synapses neurotransmitters open channels (ligand-gated channels) eg Glutamate – Na + channels; GABA – Cl - channels The Action Potential Voltage-gated channels Na + and Ca 2+ (cause depol.) and K + (cause hyperpol.) Threshold - an explosion of ionic current All-or-none; information in a neuron is digital No increase in size with increased stimulus strength Decrease in latency with increased stimulus strength Enables frequency coding: the larger the stimulus the higher
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