BIPN140 Lecture 6

BIPN140 Lecture 6 - Spontaneous activity Conductances...

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Spontaneous activity Beating/pacemaking Bursting Generated by all 4 of the conductances for beating, plus 5) a slow voltage-dependent G Na and 6) a slow voltage-dependent G K These conductances generate the slow waves of depolarization and hyperpolarization. The bursts superimposed on the peaks of V m are generated by the 4 beater conductances. Conductances generating spontaneous activity Generated by the two “squid giant axon conductances”, fast voltage-dependent G Na and fast voltage-dependent G K , plus 3) a steady voltage-independent G Na and 4) a rapidly inactivating voltage-dependent G KA . 3) produces a Na leak current that acts to depolarize the neuron in between APs; 4) slows down the rate of depolarization and return to threshold between APs.
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http://www.biology.ucsd.edu/classes/bipn140.FA10/ Cellular Neurobiology BIPN140 Lectures will now be podcast! 1st midterm exam October 19th, 5:00 pm, here Review session October 18th, 5-7 pm, Center 109 Old problem set Q&A and exam keys will be available on the website
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Figure 6.3 The structure of the nACh receptor/channel (Part 1)
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Figure 6.3 The structure of the nACh receptor/channel (Part 2)
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Figure 4.6 Topology of principal subunits of voltage-gated Na + , Ca 2+ , K + , and Cl channels (Part 1)
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Figure 4.6 Topology of principal subunits of voltage-gated Na + , Ca 2+ , K + , and Cl channels (Part 2)
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Alignment of amino acids in the S4 domain of voltage-dependent channels R = arginine; K = lysine
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Box 4B Expression of Ion Channels in Xenopus Oocytes inject K channel mRNA
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Mutational analysis of Shaker (G KA ) potassium channel activation wild type (control) R > A (mutation) (arg > ala)
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Figure 4.7 A charged voltage sensor permits voltage-dependent gating of ion channels
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Figure 4.9 Structure of a mammalian voltage-gated K + channel (Part 3)
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Figure 4.9 Structure of a mammalian voltage-gated K + channel (Part 4) paddle
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This note was uploaded on 10/30/2010 for the course BIPN BIPN 140 taught by Professor Spitzer during the Fall '07 term at UCSD.

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BIPN140 Lecture 6 - Spontaneous activity Conductances...

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