Prob Set 2(2)

Prob Set 2(2) - Problem Set 2 Cellular Neurobiology Fall...

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Problem Set 2 Cellular Neurobiology Fall 2010 1. Bill the scientist wants to use the patch clamp method to record the effects of acetylcholine on the current of a single channel. Which patch clamp configuration is most suitable for this goal? Explain how it works. Once he has isolated a channel, Bill wants to study its ion selectivity and creates the following conditions: Ion [ion]in [ion]out Na+ 150 mM 15 mM K+ 5 mM 150 mM Cl- 120 mM 10 mM Determine E ion for each of the above ions. Bill also finds that the conductances are 0.2 for Na+, 0.8 for K+, and 0.3 for Cl-. With the conditions above, he studies the current properties at various holding potentials and finds that the current changes direction at +57 mV. Given this information, to which ion(s) is this channel likely to be selectively permeable? 2. What are three characteristics of myelin that function to increase conduction velocity?
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Prob Set 2(2) - Problem Set 2 Cellular Neurobiology Fall...

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