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Bipn140 Lect 9 Notes Oct10

Bipn140 Lect 9 Notes Oct10 - BIPN 140 LECT#9 1 DKBerg...

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BIPN 140 LECT #9 1 DKBerg NEUROTRANSMITTERS/RECEPTORS I. NT Receptors A. Ionotropic Receptors: transmembrane proteins having an internal pore (“ligand-gated ion channel”) 1. Four TM domains a) nACh Receptors **FIGURE 6.3a/c**. b) GABA A & glycine Receptors 2. Three TM helices a) AMPA receptors (glutamate Rs) b) NMDA receptors (glutamate Rs) [subunit composition determines specific subtype properties, e.g. calcium-permeable vs calcium-impermeable NMDA receptors] **FIGURE 6.4a/b**. B. Metabotropic receptors 1. Seven TM regions 2. Shared NTs (with ionotropic Rs) but different outcomes: linked to intracellular pathways 3. G protein-coupled **FIGURE 6.5**. II. Classical Neurotransmitters A. Acetylcholine (ACh) 1. NT at the vertebrate NMJ 2. Rapid local synthesis: choline acetyltransferase (ChAT); defines a “cholinergic” neuron 3. Excess: desensitization of receptor **FIGURE 6.2**.
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