Bipn140 Lect 10 Notes Oct10

Bipn140 Lect 10 Notes Oct10 - BIPN 140 LECT #10 1 DKBerg...

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BIPN 140 LECT #10 1 DKBerg INTRACELLULAR SIGNALING I. General Features A. Types of cell-cell signaling 1. Synaptic (chem & elect) 2. Paracrine signaling 3. Endocrine signaling B. Signal transduction – purposes: 1. Molecular pathway from receptor to final target 2. Amplification 3. Compartmentalization **FIGURE 7.1**. **FIGURE 7.2**. C. Receptor types 1. Surface receptors – activated by cell-impermeant agonists a) ligand-gated ion channels b) G-protein-coupled receptors (GPCRs) c) many enzyme-linked receptors (e.g. receptor protein kinases) 2. Surface receptors – activated by cell-attached or transmembrane agonists (e.g. ephrin/EphB receptors) 3. Intracellular receptors – activated by cell-permeant agonists. **FIGURE 7.3**. **FIGURE 7.4**. II. GPCRs A. Heteromeric G-proteins 1. Three subunits ( ± , ² , & ³ ) 2. ± subunit binds GTP/GDP 3. Agonist ´ GPCR ´ ± binds GTP ´ ± /GTP dissociates from ²³ and interacts with target.
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BIPN 140 LECT #10 2 DKBerg 4 Termination:
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This note was uploaded on 10/30/2010 for the course BIPN BIPN 140 taught by Professor Spitzer during the Fall '07 term at UCSD.

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Bipn140 Lect 10 Notes Oct10 - BIPN 140 LECT #10 1 DKBerg...

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