Midterm 1 Solutions

Midterm 1 Solutions - BCH3170/BIO3170 Molecular Biology 1st...

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Page 1 BCH3170/BIO3170 Molecular Biology 1st Midterm (Dr. Guillet’s section) Verify that you have a complete copy exam that contains 9 pages. Clearly write your name and student number at the top of each single page of this exam. You have 80 minutes for completing this exam. This written exam is divided in 4 parts: Part 1: 5 multiple choices (15 MARKS in total) Part 2: 4 short answer questions (25 MARKS in total) Part 3: 4 long answer questions (50 MARKS in total) Part 4: please append your 1 page answer for the PDB 3CVX structure (photolyase/DNA complex) (10 MARKS in total)
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Page 2 Name: ________________________ Student #:___________ PART A MULTIPLE CHOICE QUESTIONS (15 MARKS TOTAL) 1. Choose the TWO correct answers with regard to DNA. You need the two correct answers to get your 3 marks (no partial marks). a. The pitch or rise per turn for type Z DNA is 3.4nm. b. The deoxyribose phosphate backbone is flexible and can accommodate some bending. c. In a nucleoside, the deoxyribose ring is attached at C1 of adenine d. Cytosine and guanine are two purines. e. All possible base pairs involve a match between one purine and one pyrimidine. 2. Choose the TWO correct statements. You need the two correct answers to get your 3 marks (no partial marks). a. The length of a chromosome in its highly condensed state is about 10nm. b. A nucleosome contains a core of 8 histones. c. Most histones are proteins, except for H1. d. Euchromatin has a lower packing ratio of DNA than heterochromatin. 3. Choose all three enzyme activities associated with DNA polymerase I. You need the three correct answers to get your 3 marks (no partial marks). A couple of students picked a as a correct answer. Don t forget that incoroporation is at 3 end, but overall direction for incorporation is from 5 to 3 . a. 3’to5’ DNA polymerase : b. 5’to3’ DNA polymerase c. 3’to5’ endonuclease d. 3’to5’ exonuclease e. 5’to3’ endonuclease f. 5’to3’ exonuclease 4. Choose THE best answer pertaining to the E coli clamp. ( 3 marks) a. Its central hole has a maximum diameter of 10nm. b.
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This note was uploaded on 11/02/2010 for the course BCH 3170 taught by Professor Laneuville,ekker,savage during the Spring '08 term at University of Ottawa.

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Midterm 1 Solutions - BCH3170/BIO3170 Molecular Biology 1st...

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