This preview has intentionally blurred sections. Sign up to view the full version.View Full Document
Unformatted text preview: A flexible cold microplasma jet using biocompatible dielectric tubes for cancer therapy Jae Young Kim, 1 Sung-O Kim, 1, a ! Yanzhang Wei, 2 and Jinhua Li 2 1 Holcombe Department of Electrical and Computer Engineering, Center for Optical Materials Science and Engineering Technologies, Clemson University, Clemson, South Carolina 29634, USA 2 Department of Biological Sciences, Clemson University Biomedical Institute, Clemson University, Greenville, South Carolina 29605, USA s Received 17 March 2010; accepted 23 April 2010; published online 17 May 2010 d This paper describes a flexible microplasma jet device using a Tygon ® S-54-HL tube as a biocompatible tube and its potential in developing cancer therapies. The optical and physical properties of the plasma jets and preliminary apoptosis data of cultured murine tumor cells and nontumor fibroblast cells treated with these plasma jets are presented. Microplasma jets were observed to induce apoptosis in cultured murine cells in a dose-dependent manner. The murine melanoma tumor cells were more sensitive to plasma treatment than fibroblast cells. These features allow the direct and precise application of this microplasma jet device to tumor cells. © 2010 American Institute of Physics . f doi: 10.1063/1.3431392 g Atmospheric pressure plasmas that interact with biologi- cal and medical applications have been used in a number of cancer therapies. 1 – 4 These plasmas contain many radicals with strong chemically reactive species with a very short lifespan. 5 , 6 Studies on the potential of using atmospheric pressure plasmas to treat cancer demonstrated that when ex- posed to the radicals, tumor cells undergo apoptosis quite rapidly. 1 , 2 Since there is no direct contact with the tumor tissues, plasma treatment significantly decrease the chance of complications as compared with either surgical excisions or laser treatment. A microplasma jet method has been demon- strated as one of the easiest sources for generating such at- mospheric pressure plasmas. Because a microplasma jet de- vice has a very simple structure which consists of just a tube with electrodes basically. 7 – 10 However, because these micro- plasma jets were originally developed for superficial work s i.e., treating only the surface of objects d they are rigidly inflexible due to the use of glass and quartz tubes in the design. This inflexibility makes it almost impossible for us- ing the plasma to treat interior tumors. Thus, a microplasma jet device with a flexible and biocompatible tube can result in improved targeting of formed plasmas for more precise treatment of tumor cells. For this reason, we choose polyvinyl chloride tubing sold under the trade name of Tygon ® S-54-HL from Saint- Gobain as a flexible dielectric tube....
View Full Document
- Spring '10
- Apoptosis, tumor cells, Programmed cell death, G. C. Kim