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Rho_and_cytokinesis - Inhibition of Rac by the GAP Activity...

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DOI: 10.1126/science.1163086 , 1543 (2008); 322 Science et al. Julie C. Canman, Centralspindlin Is Essential for Cytokinesis Inhibition of Rac by the GAP Activity of www.sciencemag.org (this information is current as of March 27, 2009 ): The following resources related to this article are available online at http://www.sciencemag.org/cgi/content/full/322/5907/1543 version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag.org/cgi/content/full/322/5907/1543/DC1 can be found at: Supporting Online Material found at: can be related to this article A list of selected additional articles on the Science Web sites http://www.sciencemag.org/cgi/content/full/322/5907/1543#related-content http://www.sciencemag.org/cgi/content/full/322/5907/1543#otherarticles , 15 of which can be accessed for free: cites 27 articles This article 2 article(s) on the ISI Web of Science. cited by This article has been http://www.sciencemag.org/cgi/collection/cell_biol Cell Biology : subject collections This article appears in the following http://www.sciencemag.org/about/permissions.dtl in whole or in part can be found at: this article permission to reproduce of this article or about obtaining reprints Information about obtaining registered trademark of AAAS. is a Science 2008 by the American Association for the Advancement of Science; all rights reserved. The title Copyright American Association for the Advancement of Science, 1200 New York Avenue NW, Washington, DC 20005. (print ISSN 0036-8075; online ISSN 1095-9203) is published weekly, except the last week in December, by the Science on March 27, 2009 www.sciencemag.org Downloaded from
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proves obesity-induced hepatic insulin resistance, and treatment with IL-6 can increase hepatic insulin resistance ( 12 15 ). Moreover, ablation of the IL-6 target gene Socs3 in the liver of young mice causes improved hepatic insulin sensitivity ( 16 ). Together, these data and our study demon- strate that adipose tissue derived IL-6 is an important mediator of hepatic insulin resistance and that JNK1 is a component of a metabolic stress signaling pathway that regulates IL-6 ex- pression in adipose tissue. The serum concentra- tion of IL-6 represents a possible biomarker for the evaluation of the efficacy of drugs that target JNK1 and may be useful for the treatment of metabolic diseases. References and Notes 1. J. Hirosumi et al ., Nature 420 , 333 (2002). 2. A. Jaeschke, R. J. Davis, Mol. Cell 27 , 498 (2007). 3. V. Aguirre, T. Uchida, L. Yenush, R. J. Davis, M. F. White, J. Biol. Chem. 275 , 9047 (2000). 4. C. R. Weston, R. J. Davis, Curr. Opin. Cell Biol. 19 , 142 (2007). 5. G. Solinas et al ., Cell Metab. 6 , 386 (2007). 6. D. G. Carey, A. B. Jenkins, L. V. Campbell, J. Freund, D. J. Chisholm, Diabetes 45 , 633 (1996). 7. H. Waki, P. Tontonoz, Annu. Rev. Pathol. 2 , 31 (2007). 8. B. M. Spiegelman, J. S. Flier, Cell 87 , 377 (1996). 9. J. P. Bastard et al ., Eur. Cytokine Netw. 17 , 4 (2006).
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