08-09 Inter Metab EXB101 F10

08-09 Inter Metab EXB101 F10 - EXB 101: Exercise Physiology...

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EXB 101: Exercise Physiology Lectures 9 and 10 ATP and Intermediary Metabolism
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Intermediary Metabolism Intermediary metabolism refers to the metabolism of the 3 classes of high energy molecules or macronutrients (CHO, Fats, Protein)
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Questions What is the purpose of the pathway? Under what circumstances does the pathway get turned on? How is the pathway regulated? What is the starting substrate for the pathway? What are the end products of the pathway?
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Exercise and Energy Demand • At rest, muscle utilizes ~ 1 mmol ATP/kg/min • In a sprint, the energy demand increases to 240 mmol ATP/kg/min (or 4 mmol ATP/kg/ sec).
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ATP: The Energy Currency ATP ( A denosine T ri p hosphate) constitutes the cell’s ENERGY CURRENCY since energy from ATP hydrolysis powers all forms of biologic work. Chemical energy in foods is extracted in small amounts by enzymatic reactions during metabolism This energy is captured in ATP – Conserves energy in small, reasonably sized packets of chemical energy – Energy is delivered to cellular sites as needed
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ATP, an Energy Rich Phosphate Nucleotides: molecules that consist of a pyrimidine or purine base, the sugar ribose, and one or more phosphate groups. Nucleoside= base + ribose; when the base is adenine the nucleoside is adenosine. ATP + H 2 0 ADP + P i + H + Δ G=-7.3 kcal ATP + H 2 0 AMP + PP i + H + Δ G=-10.9 kcal ATP + 2H 2 0 AMP + 2P i + 2H + Δ G=-15.5 kcal
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Additional Energy Rich Molecules (Nucleotides) GTP : guanosine triphosphate; guanine – Involved in synthesis of proteins and cell signaling UTP : uridine triphosphate; uracil – Synthesis of glycogen CTP : cytidine triphosphate; cytosine – Synthesis of RNA (in addition to ATP, UTP and GTP)
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ATP: The Common Intermediate In the cell, respiration represents the conversion of the chemical energy of foodstuffs into a useful chemical form. Cell work represents the conversion of that useful form of energy to other forms of energy or work. In order to function, this coupled system of energy-yielding and energy-utilizing reactions depends on having a substance that acts as both as energy acceptor and as an an energy donor .
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How ATP Functions as Energy Currency Substrate Product
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ATP is at an Intermediate Energy Level
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! ATP Homeostasis The ATP concentration in most cells is fairly low, about 2 to 6 mmol per kilogram of tissue. Although a muscle’s ATP can be turned over at an astonishing rate, during most kinds of physical activity, except for extreme activities such as sprinting, its content seldom decreases below the resting level. Constancy of [ATP] over wide variations of turnover is referred to as ATP homeostasis .
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ATP Homeostasis Cells, tissues and organs are designed to maintain constant cellular ATP concentrations. Adenylate Energy Charge (AEC)
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This note was uploaded on 11/02/2010 for the course GEL GEL 107 taught by Professor Jishin during the Winter '09 term at UC Davis.

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08-09 Inter Metab EXB101 F10 - EXB 101: Exercise Physiology...

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