11-12 cell repiration EXB101 F10

11-12 cell repiration EXB101 F10 - EXB 101: Exercise...

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EXB 101: Exercise Physiology Intermediary Metabolism Cellular Respiration Lectures 11 and 12
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Overview: Oxidative Metabolism Relies on oxygen to breakdown fuels for energy Produces ATP in the mitochondria of cells. Yields greater amount of energy (ATP) than anaerobic metabolism. Is the primary method of energy production during endurance events (activities lasting a minute or more). All three macronutrients (fat, CHO, proteins) can served as substrates .
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Stages of Aerobic Glycolysis 1. Glycolysis 2. PDH Reaction 3. Krebs Cycle 4. Electron Transport
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Fate of Pyruvate Generated from Glycolysis Aerobic vs. Anaebic ? Glycolytic Flux: Increase in Substrate (Pyruvate) Exercise at 40% max aerobic capacity can increase the rate of glycolysis by more than 20-fold. Cytosolic Redox State Ratio of [NADH] to [NAD + ] Aerobic Capacity Number of mitochondria Availability of Oxygen Blood flow
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How are cytosolic NAD Levels (and Redox Potential) maintained during Aerobic Glycolysis? The mitochondrial membrane is impermeable to NADH/ NAD; thus, shuttle mechanisms are necessary to move the “reducing equivalents” on NADH + H + (2 H + and 2 e - ) into mitochondria when O 2 is available for oxidative phosphorylation Malate-aspartate shuttle : “reducing equivalents are carried into the mitochondria by NADH. This shuttle appears to predominate in heart, liver and slow-twitch skeletal muscle. Glycerol phosphate shuttle : “reducing equivalents” are carried in the mitochondria by FADH 2 . This may predominate in fast twitch skeletal muscle. During electron transport and oxidative phosphorylation One NADH + H + yields 2.5 ATP One FADH 2 yields 1.5 ATP
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Muscle has two mechanisms to shuttle H + in to the mitochondria Glycerol Phosphate Shuttle Glycolytic Pathway Cytosol GPD GPD
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Muscle has two mechanisms to shuttle H + in to the mitochondria Malate-Asparate Shuttle
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(oxidative metabolism, oxidative phosphorylation) Occurs in mitochondria Interaction between two metabolic pathways – Krebs cycle (TCA cycle, Citric Acid Cycle) – Electron transport chain Mitochondrial respiration is tightly controlled and dependent on energy demand . Primary GOALS
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This note was uploaded on 11/02/2010 for the course GEL GEL 107 taught by Professor Jishin during the Winter '09 term at UC Davis.

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11-12 cell repiration EXB101 F10 - EXB 101: Exercise...

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