Week 5 Exb 110 2010 color

Week 5 Exb 110 2010 color - EXERCISEMETABOLISM EXB110...

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EXERCISE METABOLISM EXB 110 Lipid Metabolism
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Fatty Acids as Stored Energy Fatty acids are the body’s principal form of stored energy Carbon almost completely reduced as CH 2 Very closely packed in storage tissues - not hydrated as sugars are
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Dietary Fatty Acids Comprise 30-60% of caloric intake in average American diet Triacylglycerols, phospholipids, sterol esters Principal sources: dairy products, meats
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Fats and Proteins as Energy Sources • Fats can be hydrolyzed to glycerol and fatty acids – These can be modified to run through Kreb’s • Proteins can be broken down to amino acids – Which can be deaminated and run through Kreb’s • These pathways can be used to interconvert carbohydrates, fats, and proteins
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• When more energy is taken in than consumed, ATP synthesis is inhibited • Glucose converted into glycogen and fat Energy Storage
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Acetyl CoA • Is a common substrate for energy and synthetic pathways
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• Beta-oxidation clips acetyl CoAs off fatty acid chains – Which can be run thru Kreb’s giving 10ATPs each –P lus - oxidation itself yields 4 ATPs
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Lipolysis • Is breakdown of fat into fatty acids and glycerol – Via hydrolysis by lipase – Acetyl CoAs from free fatty acids serve as major energy source for many tissues
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Adipose Cell Hormone (Adrenalin, Glucagon, ACTH) Receptor (7TM) ATP c AMP Adenylyl Cyclase Activates Activates lipase Triacylglycerols Glycerol + Fatty acids Blood Lipolysis Insulin blocks this step
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Epithelial Cell (Intestinal Wall) Intestinal lumen MAG Glycerol Fatty Acids TAG Lipoprotein Chylomicrons Lymphatics Blood (bound to albumin) Adipose Tissue And Muscle
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Digestion of Dietary Triacylglycerols Occurs in duodenum Facilitated by Bile salts (emulsification) Alkaline medium (pancreatic juice)
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This note was uploaded on 11/02/2010 for the course EXB Exb 110 taught by Professor Aldringomes during the Spring '10 term at UC Davis.

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Week 5 Exb 110 2010 color - EXERCISEMETABOLISM EXB110...

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