Drugs - August 17, 2010 Topic: Drugs Addiction/Dependency:...

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August 17, 2010 Topic: Drugs Addiction/Dependency: o Increased tolerance to the drug o Physiological withdrawals when drug is reduced or ceased o Difficulty in controlling substance-taking o Increased salience of drug-seeking o Rapid reinstatement after abstinence o Only need 3 to be considered addicted/dependent Caffeine: o World’s most widely used psychoactive substance o 90% of North Americans o Adenosine: o Released by neurons and glial cells o Neurotransmitter: binds to receptors of inhibitory neurons o Neuromodulator: increases dilation of capillaries in brain (increases oxygen flow) o Caffeine binds to adenosine receptors, but without activating them (antagonist – tree branch in key slot) o Blocks inhibitory effects of adenosine o Decreases dilation of capillaries, reducing blood flow by 25% o Benefits: o Enhanced alertness, energy, coordination o Sources can promote health: Green tea consumption and reduced DNA damage Coffee and reduced heart disease in women Antioxidants, perhaps in synergy with caffeine
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Drugs - August 17, 2010 Topic: Drugs Addiction/Dependency:...

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