Senescence

Senescence - A ugust 4, 2010: Topic: Senescence Two...

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August 4, 2010: Topic: Senescence Two competing explanations Life extension strategies Doubled life expectancy: Credited largely to an improvement of public health o Fewer birth related deaths o Less infectious disease o Improved nutrition Senescence: The process or bodily deterioration that occurs at later ages o Not the same thing as aging o Diverse bodily systems deteriorate at similar rates o Old age is not a cause of death Stochastic Senescence: “random”, intricate organization constantly damaged, but usually we are able to repair it o Results from slow accumulation of wear and tear which cannot be adequately repaired: Structural damage (broken leg that never heals right) Tissue damage (atherosclerosis) Biochemical damage (DNA damage) Damage to repair systems Damage: o Caused by normal metabolic activities and environmental factors Converting food to ATP Radiation UV light Viral Infection 1,000-100,000 lesions per cell per day Only .0002% of genome Interferes with proper functioning of DNA and with DNA replication
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Repair: o
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Senescence - A ugust 4, 2010: Topic: Senescence Two...

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